Malegra 25 contains sildenafil citrate, which is a phosphodiesterase type 5 (PDE5) inhibitor. The mechanism of action of Malegra 25 in improving erections involves several key steps:
Inhibition of PDE5 Enzyme: Malegra 25 works by inhibiting the activity of the PDE5 enzyme in the smooth muscle cells of the penis. PDE5 is responsible for breaking down cyclic guanosine monophosphate (cGMP), a chemical messenger that plays a crucial role in relaxing smooth muscles and dilating blood vessels in the penis.
Increased cGMP Levels: By inhibiting PDE5, allows for increased levels of cGMP to accumulate in the penile tissues. This increase in cGMP levels promotes relaxation of the smooth muscle cells in the penile arteries and corpus cavernosum, leading to improved blood flow to the penis during sexual stimulation.
Enhanced Blood Flow: The relaxation of penile blood vessels and increased blood flow result in improved engorgement of the erectile tissues with blood. This process leads to the development and maintenance of a firm and sustainable erection that is suitable for sexual activity.
Sexual Stimulation Requirement: It's important to note that Malegra 25, like other PDE5 inhibitors, requires sexual arousal or stimulation to be effective. The medication does not induce an erection on its own but rather enhances the natural erectile response to sexual stimulation.